In early January 1941, Biloxi city officials assembled a formal offer to invite the U.S. Army Corps to build a base to support the WWII training buildup. The package included an early airport, the old Naval Reserve Park, and parts of Oak Park sufficient to support a technical training school with a population of 5,200 people.
On 6 March 1941, the War Department officially notified Mayor Braun that Biloxi had been selected. The War Department activated Army Air Corps Station No. 8, Aviation Mechanics School, Biloxi, Mississippi, on 12 June 1941. City officials wanted the base named after a notable figure in the local area's history, but it was War Department policy to name installations after service members killed in action. In late June, Mayor Braun received word that the new school would be named in honor of 2d Lt Samuel Reeves Keesler, Jr., of Greenwood, Mississippi. Lieutenant Keesler had died of wounds during World War I while serving in France as an aerial observer assigned to the 24th Aero Squadron, U.S. Army Air Service. On 25 August 1941, Army Air Corps Station No. 8 was officially designated as Keesler Army Airfield.
The 81st Training Wing replaced Keesler Training Center in July 1993, taking on the mission of specialized technical training in electronics, computers, maintenance, weather, radar, precision measurement, network controllers, and personnel and information management for the U.S. Air Force, the Air Force Reserve, the Air National Guard, other DOD agencies and foreign nations.